How to Identify High-Quality Hits Early On: Your Guide to Ensuring Reproducible In Vitro Oncology Studies

Posted by: Elie J. Diner, Ph.D. -

In the past several decades, oncology drug development has had some major successes, from the approval of game-changing therapeutics such as rituximab and trastuzumab in the late-90s to the first tumor-agnostic approval for pembrolizumab in 2017.1

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Mimicking the "Seed and Soil:" The State of PDX Models of Breast Cancer Metastases

Posted by: Elie J. Diner, Ph.D. -

Why do the quaintest analogies stick to biology’s most morbid phenomena? Look no further than English surgeon Stephen Paget’s “seed and soil” model for breast cancer metastasis for a prototypical example. In his 1889 publication in the Lancet,...

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Sarcomas vs. pharmaceutical science

Posted by: Mary Catania -

THE RIGHT TUMOR MODELS BRING GREATER CERTAINTY TO DRUG CANDIDATE SELECTION  

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Making precision oncology more personal

Posted by: Elie J. Diner, Ph.D. -

FROM GENETIC TESTING FOR CANCER TO FUNCTIONAL, PATIENT-DERIVED MODELS Genetic testing for cancer has rapidly become an important and routine part of oncology treatment. It’s driven the rise of precision oncology, where clinicians seek to match...

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Predicting Therapeutic Response & Drug Resistance with O-PDX

Posted by: Elie J. Diner, Ph.D. -

AACR 2021 Poster #2929: Predicting Patient’s Therapeutic Response and Acquired Drug Resistance with Orthotopic Patient-Derived Xenografts (O-PDX) Patient-derived xenografts (PDX) are a commonly used in vivo model that can provide clinically...

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The Subcutaneous Xenograft vs Orthotopic Xenograft Debate

Posted by: Elie J. Diner, Ph.D. -

Subcutaneous vs Orthotopic Xenografts: Identifying Clinically Relevant Models for Making More Accurate, Personalized Cancer Treatment Decisions In our last blog, we explored some of the current gaps in personalized medicine and how...

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Making More Accurate, Personalized Cancer Treatment Decisions With Clinically Relevant PDX Models, Part 1

Posted by: Elie J. Diner, Ph.D. -

In the past few decades, researchers and clinicians have gained a deep understanding of the biology behind tumor growth and metastasis and the clinical course for many different types of cancers. Despite these advancements, cancers are still treated...

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Precision Oncology as a Model for Bridging the “Valley of Death”

Posted by: Kristein King -

A persistent challenge in anti-cancer drug development remains translation from animal studies to human clinical trials. A shocking 57% of late-stage oncology trials fail due to inadequate efficacy. These failures amount to billions of dollars in...

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Orthotopic PDX: The Gold Standard in Precision Oncology

Posted by: Kristein King -

On December 15th, 2020, Dr. Jonathan Nakashima, PhD, CSO of Certis Oncology, joined Taconic Biosciences to present a comprehensive overview of O-PDX testing.  O-PDX is a technique which uses in vivo pharmacology testing in personalized mouse models,...

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